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张成

张成

职称:副研究员

研究所:软件研究所

研究概况:https://www.researchgate.net/profile/Cheng-Zhang-103

办公电话:86-10-62750359

电子邮件:zhangcheng369@pku.edu.cn

课题组网站:http://www.pku-zhang.com



研究简介:

从事生物计算(DNA计算和分子电路)、DNA存储、纳米孔测序、生物信息技术、纳米智能机器等方面研究。近年来,以第一或通讯作者在Science Advances (2022), J. Am. Chem. Soc. (2019), Nano Letters (2016), Nucleic Acids Research (2020, 2019, 2018), Biosensors & Bioelectronics (2021),中国科学 (2015), 科学通报 (2014)等学术期刊上发表科研论文40余篇。

作为负责人主持科研项目:国家重点研发计划课题(2022)、国家重点研发计划政府间重点专项(2019)、国家自然科学基金(2019,2017,2013)、北京市联合研发大科学计划专项(2020)、教育部装备联合基金(2018)、北京市自然科学基金(2018)等。参与科研项目:基金委重大应急项目(2017)、国家自然基金重点项目(2013)、国家基金委重大仪器专项(2012)等。申请发明专利7项,获授权4项。入选2020年中国科学院创新交叉团队。


科研/教育经历:

2007-2010,博士,北京大学

2010-2012,博士后,北京大学

2013-至今,北京大学任教

2014.10-2015.10,美国亚利桑那州立大学,访问学者

2010.09-2011.11,美国普渡大学,访问学者


代表性论文:(*通讯作者)

1.Zhang Cheng*, Xueying Ma, Xuedong Zheng, Yonggang Ke, Kuiting Chen, Dongsheng Liu, Zuhong Lu, Jing Yang, Hao Yan. Programmable Allosteric DNA Regulations for Molecular Networks and Nanomachines. Science Advances, 2022.

2.Taoli Ding, Jing Yang, Victor Pan, Zuhong Lu, Yonggang Ke, Zhang Cheng*, Shaped DNA Origami Carrier Nanopore Translocation Influenced by Aptamer based Surface Modification. Biosensors & Bioelectronics, 2021.

3.Taoli Ding, Jing Yang, Victor Pan, Nan Zhao, Zuhong Lu, Yonggang Ke and Zhang Cheng*, DNA nanotechnology assisted nanopore-based analysis,  Nucleic Acids Research, 2020.

4.Zhang Cheng*, Zhiyu Wang, Yan Liu, Jing Yang, Xinxin Zhang, Linqiang Pan, Yonggang Ke, Hao Yan. Nicking Assisted Reactant Recycle to Implement Entropy-Driven DNA Circuit, J. Am. Chem. Soc., 2019.

5.Xuedong Zheng, Jing Yang, Changjun Zhou, Zhang Cheng*, Qiang Zhang, Xiaopeng Wei, Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis, Nucleic Acids Research, 2019.

6.Yang Jing, Wu, Ranfeng, Wang Zhiyu, Pan Linqiang, Zhang Qiang, Lu Zuhong, Zhang Cheng*, Entropy-Driven DNA Logic Circuits Regulated by DNAzyme, Nucleic Acids Research, 2018.

7.Cheng Zhang*, Jing Yang, Shuoxing Jiang, Yan Liu and Hao Yan, DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly. Nano Letters, 2016.

8.Jing Yang, Shuoxing Jiang, Xiangrong Liu, Linqiang Pan, Cheng Zhang*, Aptamer-Binding Directed DNA Origami Pattern for Logic Gates, ACS Appl. Mater. Interfaces, 2016.

9.Yafei Dong, Chen dong, Fei Wan, Jing Yang and Cheng Zhang*, Development of DNA computing and information processing based on DNA-strand displacement, 中国科学, 2015.

10.Jing Yang, Jingjing Ma, Shi Liu, Zhang Cheng*, A molecular cryptography model based on structures of DNA self-assembly, 科学通报, 2014.